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Published preclinical work used a wide range of oral doses

It reduced lines and wrinkles, improved skin density, and increased skin thickness better than both placebo and vitamin K cream

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The absorption of B12 is a complicated process but the two main components that are needed are the Hydrochloric acid in your stomach, which releases the B12 from food, and a protein called Intrinsic Factor which is produced in the lining of your stomach and which enables the absorption of B12 in the Ileum