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Tirzepatide is frequently described in the literature as a twincretin because trial data shows it activating GLP-1 and GIP receptors with a more balanced potency profile than earlier compounds in the class
This allows for personalized dosing and ensures that patients can continue their treatment even when branded supplies are limited
Epigenetic regulation: Beyond immediate gene expression, some peptides create lasting epigenetic changes (DNA methylation, histone modifications)
El receptor de GLP-1 (GLP-1R) pertenece a la familia de receptores de glucagn acoplados a protenaG de claseB2,3
Schwaitzberg 2017
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