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In an I/R-mediated myocardial injury model, pretreatment with Tan IIA activated the GSH system by increasing Nrf2 expression [154]

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doi: 10.1016/j.jocrd.2020.100529 19 LiberatiAAltmanDGTetzlaffJMulrowCGtzschePCIoannidisJPet al

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Less controversially, the second phase is likely caused by direct stimulation of L-cells by digested nutrients

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