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Scafidi S, et al

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice

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The researchers noted that the more weight the patient lost, the more likely they were to stick with the drugs

A1C cannot identify an immediate low-glucose episode