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This effect was inhibited by endothelium removal or NOS blockade, indicating that NO plays a crucial role in the vasodilatory response

DOI: 10.1016/j.ebiom.2021.103618 [Google Scholar] Meurot C, Martin C, Sudre L, Breton J, Bougault C, Rattenbach R, et al

335,336 The expression of iNOS is primarily activated by the NF-B pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS