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Since tirzepatide slows gastric emptying, smaller meal volumes reduce the likelihood of gastric distension and reflux of air

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For instance, some employers choose to exclude GLP-1 drugs from employer-sponsored health plans, some insurance plans require prior authorization before approval, and Medicare does not cover GLP-1s for weight loss

Proton pump inhibitors (PPIs) such as omeprazole or pantoprazole may help patients experiencing concurrent reflux symptoms, as delayed gastric emptying can worsen gastroesophageal reflux disease

On withdrawal, the pressure differential forces peptide solution backward through the needle