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Often, patients with thiamine deficiency have concomitant nutritional deficiencies (such as B12 in this case), which can contribute to additional neurological symptoms and signs, such as optic atrophy in this case [1]
Most manufacturers list a shelf life of 23 years from the manufacture date when stored correctly
As a result, the activity of the electron transport chain (ETC) is hindered, decreasing ATP production during oxidative phosphorylation [8]
Most of it is broken down in the gut before reaching systemic circulation
Neuropediatrics 23, 147152
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