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The COMBO-DN study was a large, double-blind, randomized clinical trial that compared the efficacy and safety of high-dose monotherapy versus combination therapy with duloxetine and pregabalin in patients with DPN who had not responded to standard doses [126]

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10.1016/j.freeradbiomed.2020.10.002 Free Radic Biol Med

Patience and consistency essential for meaningful outcomes

In less than 24 hours, the two largest biopharmaceutical companies presented these blockbuster diabetes and obesity treatments as the worlds first recognized longevity therapeutics