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In studies with rodents, Ozempic and medicines that work like Ozempic caused thyroid tumors, including thyroid cancer
Some individuals carry genetic predispositions in metabolic and appetite-regulation pathways that may influence how aggressively GLP-1 discontinuation affects weight regain
While real-world Tirzepatide dose escalations were slower than those observed during the drug's clinical trials, with many patients remaining on lower doses such as 5 mg or 7.5 mg even after six months due to factors like off-label prescribing practices, supply constraints, or provider and patient preferences, patients who persisted with the medication for at least 6 months witnessed a mean weight reduction of 12.9% among a subset of persistent, GLP-1 naive patients, not the entire cohort compared to baseline values
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