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Key milestones in exenatides development include: Preclinical Testing: Amylins researchers found exenatide was a full agonist at the human GLP-1 receptor, mimicking all the effects of GLP-1 stimulating glucose-dependent insulin release, inhibiting glucagon, slowing gastric emptying, and reducing food intake ( [91] ) ( [92] )

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10.3390/cells9061528 Cells 23 HanS

Resistant to stomach acid and stable at room temperature, it has shown remarkable regenerative effects in preclinical studies, particularly for gastrointestinal healing