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Emma F, Hoff WV, Hohenfellner K, Topaloglu R, Greco M, Ariceta G, Bettini C, Bockenhauer D, Veys K, Pape L, Hulton S, Collin S, Ozaltin F, Servais A, Deschenes G, Novo R, Bertholet-Thomas A, Oh J, Cornelissen E, Janssen M, Haffner D, Rava L, Antignac C, Devuyst O, Niaudet P, Levtchenko E (2021) An international cohort study spanning five decades assessed outcomes of nephropathic cystinosis

Goals of Treatment Achieve blood sugar goals

Metformin Metformin is generally weight-neutral but may cause modest weight loss if youre prediabetic, newly diagnosed with type 2 diabetes, or overweight

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mTORC1 further supports glycine synthesis by enhancing glycolytic flux and glucose uptake, contributing to a self-reinforcing cycle that sustains collagen production [108, 109]