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The WHO estimates it affects between 1020% of people infected with SARS-CoV-2 tens of millions globally.1 The symptoms are wide-ranging but cluster into recognizable patterns: Neurological: brain fog, cognitive impairment, headaches, sleep disruption Cardiovascular: chest pain, breathlessness, tachycardia (POTS), reduced exercise tolerance Immune: persistent low-grade inflammation, recurrent infections, autoimmune flares Musculoskeletal: post-exertional malaise (PEM), joint pain, muscle weakness Metabolic/endocrine: insulin dysregulation, thyroid disruption, adrenal fatigue signals Standard care rest, symptom management, antidepressants, rehabilitation programs helps some patients

Administration of the Si-based agent significantly alleviated UC inflammation symptoms To examine whether inflammation of the large intestine, the primary symptom of UC, was suppressed by administration of the Si-based agent, MRI of the UC model mice was performed on the 5th day after DSS administration

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These nanocarriers were useful in addressing bioavailability difficulties caused by short half-life, substantial first-pass hepatic metabolism, and poor BBB penetration (182)