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When adding a GLP-1 to an existing Tresiba regimen, most guidelines recommend reducing the Tresiba dose by approximately 20% to avoid hypoglycemia as the GLP-1 begins its own glucose-lowering effects

A total of 833 participants died during the study, of which 58% were related to cardiovascular causes and 42% from others, with infections being the most common cause of death in this latter group