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The 28% nausea rate is dramatically lower than Wegovys 44%, and the discontinuation rate of 11.2% is reasonable given the unprecedented efficacy

Despite being originally developed for diabetes, theyve become synonymous with weight loss at this point

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| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx

Cerovecki T, et al