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For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies

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It works by mimicking the natural GHRH peptide 1 , which is produced in the hypothalamus, to stimulate the release of growth hormone (GH) from the pituitary gland

doi:10.3389/fimmu.2015.00270