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Inconsistencies in early studies of NOs role in LTP largely appear to have stemmed from species differences in NO synthesis, with C57BL/6J mice and human tissue exhibiting more robust hippocampal nNOS expression and LTP across the lifespan than Sv129 mice or rats ( Accordingly, though not always without controversy, NO co-transmission has been implicated in many forms of learning

The NHS symptoms list groups them into general anaemia symptoms (tiredness, breathlessness, headaches, loss of appetite, weight loss) and neurological signs (peripheral neuropathy, balance problems, depression, memory and concentration changes, sometimes mood changes or psychosis in advanced cases)