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According to the FDA's Orange Book, the earliest patents are not expected to expire until the late 2020s or early 2030s, depending on patent extensions and exclusivity periods granted by the FDA

Timing: Results vary, but most women feel improvements in inflammation, digestion, and energy within 24 weeks, with continued benefits over 812 weeks

The researchers found that allulose: Stimulated GLP-1 secretion from intestinal cells Activated beneficial metabolic pathways Improved glucose tolerance Demonstrated chronotherapeutic effects on metabolism Additional research published in Nutrients (2022) showed that allulose works synergistically with GLP-1, activating specific neurons in the brain's appetite control centers, leading to reduced food intake in test subjects

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doi:10.1016/j.envres.2013.07.005