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Tirzepatide: SURMOUNT-MMO At time of publication, the SURMOUNT-MMO trial evaluating tirzepatides cardiovascular outcomes in a similar population is ongoing

The World Health Organization conditionally recommended glucagon-like peptide-1 (GLP-1) therapies for obesity treatment in December 2025, marking a significant shift in global health policy that could influence Canadian coverage decisions

d-lactate acidosis is a rare complication of jejuno-ileal bypass surgery or patients with short bowel syndrome (SBS) (184)

Generally, the selection of a GLP-1 RA should involve consideration of available evidence in conjunction with relevant patient-specific factors such as CV risk, cost, and patient adherence

Treatment typically involves a medical evaluation to determine if it is appropriate, followed by ongoing monitoring to ensure safety and effectiveness