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After an initial 60 weeks on Zepbound at the MTD, participants either continued on the MTD, reduced the dose to 5 mg, or received a placebo
Limitations This study has several limitations that warrant consideration
Furthermore, acetylcarnitine has been demonstrated to facilitate the release of neurotransmitters (e.g., norepinephrine, serotonin, dopamine, and gamma-aminobutyric acid)
Human trials are ongoing, but even modest effects in opioid use disorder could be clinically meaningful given the favorable safety profile of GLP-1 drugs compared with existing treatments
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
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