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Potential Side Effects The GLP-1 receptor agonists type medications interfere with absorption and utilization of vitamins and minerals in the body which may lead to nutrient depletion, loss of muscle mass and changes in facial appearance
2025 Jun;53:101890
Where f u,p is the unbound fraction of the compound (inhibitor) in the plasma, IC 50 is the half-maximal inhibitory concentration, and I in,max is the estimated maximum plasma compound concentration at the liver inlet, which was calculated using Equation 10
In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]
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