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Its natural role is to coordinate the body's response to a meal: stimulating insulin secretion, suppressing glucagon, slowing the rate at which the stomach empties its contents into the small intestine, and signaling to the brain that energy has arrived and appetite can be reduced

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Patients should be counselled about common gastrointestinal symptoms, advised to start with the lowest dose (2.5 mg weekly), and informed that side effects typically improve over 4-8 weeks as tolerance develops

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Poor preparation occurs in less than 10% of cases when evidence-based protocols are followed properly