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The overall proposed effect is lower blood-pressure burden, reduced endothelial stress, and support for cardiovascular health
The primary endpoint is a renal composite episode defined by a decrease in GFR 50%, end-stage renal failure, and death from a renal-cause or cardiovascular-caused death, and it is scheduled for completion in 2024
The research article noted the following findings: 44% lower all-cause mortality 31% lower risk of pulmonary embolism 17% lower risk of venous thromboembolism 21% lower emergency department visits Earlier studies have shown similar results in people with diabetes and chronic kidney disease (CKD)
Semaglutide and tirzepatide are both GLP-1 receptor agonists, but tirzepatide is a dual-agonist that also activates GIP receptors
PMID: 23343870
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