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If neurological involvement is suspected, treatment should be started urgently and must not be delayed whilst awaiting blood test results

ZM, GS, and HV conducted the formal analysis

Therefore, working closely with a licensed healthcare practitioner is highly recommended before attempting to initiate any new treatment cycle

We also observed frequent overlap between FOXO4 and p53bp1 foci, indicating an interaction and co-localization between FOXO4 and p53 in the nuclei of senescent cells (Figure