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Common gastrointestinal side effects occur in many patients and include: Nausea (most common, typically improving after 4-8 weeks) Vomiting Diarrhea Constipation Abdominal pain or discomfort Decreased appetite These effects result from the drugs' mechanism of actionslowing gastric emptying and affecting gut motilityrather than indicating tissue damage or malignancy

This 1.6:1 ratio of fat-to-lean mass loss compares favorably to other weight loss interventions and significantly exceeds the typical 2:1 or 3:1 ratios seen with caloric restriction alone

doi: 10.1016/j.fct.2013.10.023 47 ShehataA

Tirzepatide has consistently shown greater weight loss than semaglutide at comparable doses in clinical trials, with some participants losing approximately 16% or more of their starting body weight. Choosing between the two compounds is a clinical decision based on individual health history, metabolic profile, and treatment goals, not simply which drug produces the largest number on paper

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