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Changes in HbA1c levels from baseline to week 26 was the primary efficacy endpoint measure by the research team while the secondary efficacy endpoints measure at week 26 included the proportion of patients achieving HbA1c target levels of less than 7.0%

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2.4 Assessment of anthropometric and biochemical parameters At baseline (timepoint 1), at the end of semaglutide intervention (timepoint 2), and at the end of the study (timepoint 3), all participants underwent body weight assessment

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You can explore related research at PubMed: Pickart, GHK and tissue remodeling (PMID 9763764)