The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 356:147154
You may also use GHK-copper as a supplement for Skin Biology cosmetics
This guide addresses the research context using 20mg vials available through those channels
If youre impatient, vitamin C might win