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Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial

The studys results provide insights into some known and previously unrecognized benefits and risks of GLP-1RA that may be useful to inform clinical care and guide research agendas. Al-Aly emphasized that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach

Soon after, CMS announced that it would cover Wegovy for this use, and specifically for patients with body mass index of at least 27 kg/m 2

Adjust your fiber intake gradually

Bowel Obstruction Like intestinal obstructions, a blockage of the large intestine or colon can lead to major health emergencies