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"Oral Vitamin B12 Supplementation After Roux-en-Y Gastric Bypass: a Systematic Review"

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When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss

That process is slow, and for some people it is not very efficient