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You May Have Gastrointestinal Side Effects These [issues] occur because semaglutide slows down digestion, says Jessica Cutler, MD, a weight loss surgeon with the Maryland Bariatric Center at Mercy Medical Center in Baltimore

I listened to a really long conversation, a podcast about it

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In trials, patients on the highest dose lost an average of 22.5% of body weight

Interestingly, estrogen signaling may be necessary for GLP-1 action