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A total of 40 participants were selected and randomized into two sequences in a double-blind, placebo-controlled crossover design, with a one-week washout period between treatments to eliminate carryover effects

In reaction order these enzymes are GTP cyclohydrolase 1 (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS), and sepiapterin reductase (SR)

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