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Lower starting concentrations (2-4%) are recommended for darker skin phototypes, with gradual titration every 1-2 weeks while monitoring for erythema, irritation, or PIH development

Elevated fatty acids (FAs) activate Toll-like receptors (TLRs) in macrophages, which act in synergy with MSU crystals to trigger NLRP3 inflammasome activation and pro-inflammatory cytokine release (e.g., IL-1), thereby initiating the inflammatory cascade

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PMID: 33507118

In fact, low intake has been linked to increased risk of fracture and osteoporosis ( Research has found that vitamin C plays a critical role in bone formation, so a deficiency can increase the rate of bone loss ( Childrens skeletons may be especially affected by vitamin C deficiency, as they are still growing and developing ( Summary Vitamin C is important for bone formation, and deficiency can increase the risk of developing weak and brittle bones