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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)
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The mice were housed and bred under specific pathogen-free conditions at the Luxembourg Institute of Health (LIH) and the BTA facility of the University of Luxembourg
Bioactive components of polyphenol-rich and non-polyphenol-rich cranberry fruit extracts and their chemopreventive effects on colitis-associated colon cancer
This is the required route under the Medicines for Human Use (Clinical Trials) Regulations 2004 (as amended) and MHRA/HRA guidance on CTIMP safety reporting
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