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This enzyme achieves this promiscuity primarily through rapid transpersulfidation of C201 in a CstB-unique loop relative to a canonical PDO, followed by molecular shuttling of a covalently bound sulfonate group to a persulfidated C408, and thiosulfate release

This study suggests that the increase of mutant allele number of T in C677T locus will enhance stress risk for depression 71

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The FDA prohibits its sale or use as a drug, supplement, or treatment in humans