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Waiting until significant loss has occurred reduces potential for recovery

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What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data

This review looks at the molecular composition, mechanism of action and research applications of both substances, essential information for researchers in this field