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DPP-4 inhibitors (also known as gliptins), oral medications which modestly increase endogenous incretin levels and have no impact on cardiovascular outcomes or body weight
That, it seems worth pointing out, is both a loss and a reason to pay closer attention
The mutation of GIPR Glu 354 to Gln increases GIP affinity, enhances the agonist residence time by 25%, increases cAMP activity, and facilitates the rate of internalization by 2.12.3-fold
Cardiovascular outcomes trials have shown reduced rates of major adverse cardiac events
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