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Despite its promising potential, limited high-quality donor hepatocytes and poor engraftment and repopulation hinder large-scale clinical use
The most commonly reported side effects were injection site reactions (redness, swelling), transient facial flushing, and occasional headache
Potential downsides include cost compared to oral supplements, need for clinic visits, possible minor side effects (headache, vein irritation), and rare allergic reactions
Moreover, the use of GST 4QN as a tag reduced fused p53 aggregation and enhanced the induction of p21 transcription and apoptosis in cells treated with 5-fluorouracil (5-FU)
It drives neuronal mitochondrial biogenesis through CREB-PGC-1 signaling, a pathway that can bolster cellular resilience to stress
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