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In addition to liver outcomes (cirrhosis and HCC), MASLD is associated with an increased risk of developing de novo T2D, chronic kidney disease, sarcopenia, and extrahepatic cancers

16.Interactions Between Glucagon Like Peptide 1 (GLP-1) and Estrogens Regulates Lipid Metabolism.Biochemical Pharmacology

doi:10.1056/NEJMoa2032183.Opens in a new tab Wadden TA, Bailey TS, Billings LK, et al

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It deserves deeper exploration because it is the most actionable factor and the one with the most long-term consequences