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Ferroptosis: mechanisms and links with diseases

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The GGH gene is located on chromosome 8q12.3 and is composed of 10 exons that generate two alternatively spliced mRNAs encoding precursor proteins of 318 amino acids (isoform 1) and 271 amino acids (isoform 2)

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It has been proposed to diagnose this specific form of cholangiocarcinoma as cholangiocarcinoma, intestinal type (Greaves 2007), but that nomenclature as a separate (sub-) diagnosis was not favorably encouraged at a recent scientific workshop (NTP Satellite Symposium 2010)

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