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More importantly, ME-3 has been shown to substantially reduce levels of oxidized LDL-cholesterol. Since oxidized LDL-cholesterol is one of the greatest risk factors for heart disease, ME-3s ability to reduce levels of oxidized LDL-cholesterol is a significant factor in promoting cardiovascular health. 4) Promotes detoxification: Since ME-3 substantially increases glutathione levels, scientists assume it will increase glutathiones detoxification capabilities

Eur J Pharmacol 829:7078

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This leads to brown or black patches on the lips

J Biol Chem 2007