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Oral semaglutide requires higher doses to achieve equivalent systemic exposure and depends on gastric pH and intestinal motility for absorptionboth factors affected by GLP-1 therapy itself and potentially complicated by renal disease
Most patients experience gradual improvement over time, though a minority may have persistent symptoms requiring dose adjustment or treatment review
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Vranekovi J, Babi Bozovi I, Starcevi Cizmarevi N, et al
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