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Some of them are working additional jobs or delaying retirement so they can continue to pay for it.
It may be a fit for patients who: Have appetite regulation challenges Have signs of insulin resistance Have struggled with repeated weight loss attempts Need stronger metabolic support Have not responded as expected to other approaches Have a medical history that supports tirzepatide use Can tolerate the medication appropriately Tirzepatide may be appealing because of its dual-hormone mechanism, but stronger does not always mean better for every person
Common gastrointestinal adverse effects associated with semaglutide include: Nausea (reported in up to 44% of patients on Wegovy, 20% on Ozempic, and 15% on Rybelsus) [2] [4] Vomiting Diarrhea Constipation Abdominal pain or discomfort Dyspepsia These effects are typically dose-dependent and most pronounced during the initial titration phase, with higher rates observed at weight management doses compared to diabetes doses
It means that the millions of people with obesity who aren't candidates for surgery, or who prefer a non-surgical approach, could access comparable results through a pharmacological treatment
Trial FLOW (Perkovic et al., NEJM 2024) Design Phase 3 / event-driven Population 3,533 adults with T2D and CKD Key result 24% reduction in kidney disease progression and CV death (HR 0.76
