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Reducing GLP-1 Side Effects and Supporting Digestive Health Starting at the lowest effective dose and increasing gradually allows your stomach to adjust to GLP-1's effects over weeks rather than days

by Dennis Crouch Since late 2022, the extraordinary demand for glucagon-like peptide-1 receptor agonists (GLP-1s) like Eli Lilly's tirzepatide (marketed as Mounjaro for diabetes and Zepbound for weight loss) has created a persistent nationwide shortage

Individual factors such as baseline gut sensitivity, concurrent medications (especially metformin, which can independently cause diarrhea), and pre-existing conditions like irritable bowel syndrome significantly influence whether diarrhea develops and its severity

GLP-1s caloric deficit depletes it faster than your body replenishes it

Its possible that the temperature will be even higher at night compared to during the day