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Brand-name Mounjaro and Zepbound carry expiration dates of 12 to 18 months from manufacture, while compounded tirzepatide typically has beyond-use dates of 28 to 90 days from compounding

More than 6 episodes daily for more than 48 hours: High-frequency diarrhea risks significant dehydration

Conservative doses may fall below effective threshold for some individuals

Concomitant medications that are sensitive CYP3A4 substrates may require monitoring with or without dose reductions, according to the individual respective product labeling, as summarized in Supplementary Table 3

Ozempic is administered through an injection once a week and is typically used in conjunction with a healthy diet and exercise program