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On the other hand, Hb can directly scavenge NO through a dioxygenation reaction, thereby reducing NO bioavailability (Kato et al., 2017)

Tirzepatide is approved under two brand names: Mounjaro for type 2 diabetes (FDA May 2022) and Zepbound for chronic weight management (November 2023) and moderate-to-severe obstructive sleep apnoea with obesity (December 2024) 28

Additionally, mean monthly headache days were significantly reduced in the exenatide group compared to placebo, further supporting its therapeutic potential [99]

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The team then tracked the medical records of these patients over the following year, looking for things related to severe migraine headaches, such as emergency room visits, hospitalizations, nerve block procedures, and new prescriptions for medications used to prevent or stop migraines