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It was not until a genetically engineered strain of Pseudomonas denitrificans was used, in which eight of the genes involved in the biosynthesis of the vitamin had been overexpressed, that the complete sequence of methylation and other steps could be determined, thus fully establishing all the intermediates in the pathway

But the obvious follow-up question is: by how much, and in whom

Front Endocrinol (Lausanne) 11:178

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DNA damage induced by ROS triggers the bacterial SOS response, activating repair enzymes and stress-response genes to mitigate such damage