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Long-term testing: Conduct long-term tests under recommended storage conditions to observe changes in the physical and chemical properties of the cream and determine its validity period

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We defined S to be a factor multiplying the V max values of GCL and GPX representing the activation of GCL and GPX, so S = 1 for males and S = 1.8 for females for average estradiol, since we make a case based on experimental and clinical results that the activation is by 80%