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Reported, but not confirmed Important limits Could relate to the compound, concentration, sterility, or injection method
In the male patient for instance, D50.0 may result in a review for hidden bleeding
It may also be prescribed for certain cobalt deficiencies, certain pancreatic diseases or intestinal malabsorption conditions
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified
