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Clinical trials demonstrate average weight reductions of approximately 15% with semaglutide 2.4 mg (STEP 1 trial) and 20-22.5% with tirzepatide 10-15 mg (SURMOUNT-1 trial) over 68-72 weeks

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non-responders were those with less than 5% TBWL

B.et al (2014)

Effect of pine bark extract and its phenolic compounds on selected pathogenic and probiotic bacterial strains