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While GLP-1s have been proposed to exert beneficial effects on inflammation, synaptic preservation, and microglia/astroglia function, Tan explained, it has very limited ability to cross the blood-brain barrier, where the reduction of insulin resistance in the central nervous system is really needed. In line with these sentiments, Christopher U

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showed TMAO activates Wnt3a/-catenin in atrial fibroblasts, inducing -catenin nuclear translocation and TGF-1 upregulation, promoting fibroblast-to-myofibroblast transformation (Yang et al., 2022)

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