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Selectively targeting glutamine uptake by L--Glutamyl-p-nitroanilide (GPNA), an inhibitor of glutamine transporter SLC1A5, showed a reduction of tumor proliferation in a preclinical 3D model and tumor growth suppression in a xenograft when combined with castration of mice [152]
However, participants were only followed for 12 weeks in both studies
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The combination has been associated with elevated sirtuin activity, altered adipocyte differentiation markers, and changes in muscle stem cell quiescence and proliferation in the cited preclinical literature
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